Opsis Therapeutics

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Retinal diseases cause irreversible vision loss. We are developing therapeutics designed to repair the retina, with the goal of improving vision for millions of patients.

 

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Selected References:

 
Selected References
iPSC-Derived Retina Transplants Improve Vision in rd1 End-Stage Retinal-Degeneration Mice

Momo Fujii, Tomoyo Hashiguchi, Genshiro A. Sunagawa, Shinichiro Ito, Jianan Sun, Jun Kaneko, Junki Sho, Chikako Yamada, Masayo Takahashi

Stem Cell Reports, Volume 8, Issue 1, p69–83, 10 January 2017

Successful Transplantation of Retinal Pigment Epithelial Cells from MHC Homozygote iPSCs in MHC-Matched Models.

Sugita S, Iwasaki Y, Makabe K, Kamao H, Mandai M, Shiina T, Ogasawara K, Hirami Y, Kurimoto Y, Takahashi M.

Stem Cell Reports. 2016 Sep 13.

Cell-Based Therapy for Degenerative Retinal Disease.

Zarbin M.

Trends Mol Med. 2016 Feb;22(2):115-34.
 

Report on the National Eye Institute Audacious Goals Initiative: Photoreceptor Regeneration and Integration Workshop.

Gamm DM, Wong R; and the AGI Workshop Panelists.

Transl Vis Sci Technol. 2015 Nov 17;4(6):2.

Transplantation of human embryonic stem cell-derived retinal tissue in two primate models of retinal degeneration.

Shirai H, Mandai M, Matsushita K, Kuwahara A, Yonemura S, Nakano T, Assawachananont J, Kimura T, Saito K, Terasaki H, Eiraku M, Sasai Y, Takahashi M.

Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):E81-90.

Generation of highly enriched populations of optic vesicle-like retinal cells from human pluripotent stem cells.

Ohlemacher SK, Iglesias CL, Sridhar A, Gamm DM, Meyer JS.

Curr Protoc Stem Cell Biol 2015;32:1H 8 1-1H 8 20.

Generation of three-dimensional retinal tissue with functional photoreceptors from human iPSCs.

Zhong X, Gutierrez C, Xue T, et al.

Nat Commun 2014;5:4047.

Induced pluripotent stem cells as custom therapeutics for retinal repair: progress and rationale.

Wright LS, Phillips MJ, Pinilla I, Hei D, Gamm DM.

Exp Eye Res 2014;123:161-172.

Modeling human retinal development with patient-specific induced pluripotent stem cells reveals multiple roles for visual system homeobox 2.

Phillips MJ, Perez ET, Martin JM, et al.

Stem Cells 2014;32:1480-1492.

Blood-derived human iPS cells generate optic vesicle-like structures with the capacity to form retinal laminae and develop synapses.

Phillips MJ, Wallace KA, Dickerson SJ, et al.

Invest Ophthalmol Vis Sci 2012;53:2007-2019.

Optic vesicle-like structures derived from human pluripotent stem cells facilitate a customized approach to retinal disease treatment.

Meyer JS, Howden SE, Wallace KA, et al.

Stem Cells 2011;29:1206-1218.

Modeling early retinal development with human embryonic and induced pluripotent stem cells.

Meyer JS, Shearer RL, Capowski EE, et al.

Proc Natl Acad Sci U S A 2009;106:16698-16703.

Daylight vision repair by cell transplantation.

Santos-Ferreira T, Postel K, Stutzki H, Kurth T, Zeck G, Ader M.

Stem Cells 2015;33:79-90.

Migration, integration and maturation of photoreceptor precursors following transplantation in the mouse retina.

Warre-Cornish K, Barber AC, Sowden JC, Ali RR, Pearson RA.

Stem Cells Dev 2014;23:941-954.

Subretinal transplantation of MACS purified photoreceptor precursor cells into the adult mouse retina.

Eberle D, Santos-Ferreira T, Grahl S, Ader M.

J Vis Exp 2014;e50932.

Repair of the degenerate retina by photoreceptor transplantation.

Barber AC, Hippert C, Duran Y, et al.

Proc Natl Acad Sci U S A 2013;110:354-359.

Restoration of vision after transplantation of photoreceptors.

Pearson RA, Barber AC, Rizzi M, et al.

Nature 2012;485:99-103.

Retinal repair by transplantation of photoreceptor precursors.

MacLaren RE, Pearson RA, MacNeil A, et al.

Nature 2006;444:203-207.

Developing rods transplanted into the degenerating retina of Crx-knockout mice exhibit neural activity similar to native photoreceptors.

Homma K, Okamoto S, Mandai M, et al.

Stem Cells 2013;31:1149-1159.

Photoreceptor precursors derived from three-dimensional embryonic stem cell cultures integrate and mature within adult degenerate retina.

Gonzalez-Cordero A, West EL, Pearson RA, et al.

Nat Biotechnol 2013;31:741-747.

Transplantation of adult mouse iPS cell-derived photoreceptor precursors restores retinal structure and function in degenerative mice.

Tucker BA, Park IH, Qi SD, et al.

PLoS One 2011;6:e18992.

Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative mice.

Assawachananont J, Mandai M, Okamoto S, et al.

Stem Cell Reports 2014;2:662-674.

Generation, purification and transplantation of photoreceptors derived from human induced pluripotent stem cells.

Lamba DA, McUsic A, Hirata RK, Wang PR, Russell D, Reh TA.

PLoS One 2010;5:e8763.

Transplantation of human embryonic stem cell-derived photoreceptors restores some visual function in Crx-deficient mice.

Lamba DA, Gust J, Reh TA.

Cell Stem Cell 2009;4:73-7

Advancing therapeutic strategies for inherited retinal degeneration: recommendations from the Monaciano Symposium.

Thompson DA, Ali RR, Banin E, et al.

Invest Ophthalmol Vis Sci 2015;56:918-931.

Using human induced pluripotent stem cells to treat retinal disease.

Borooah S, Phillips MJ, Bilican B, et al.

Prog Retin Eye Res 2013;37:163-181.

Patient-specific induced pluripotent stem cells (iPSCs) for the study and treatment of retinal degenerative diseases.

Wiley LA, Burnight ER, Songstad AE, et al.

Prog Retin Eye Res 2015;44:15-35.

Cellular strategies for retinal repair by photoreceptor replacement.

Jayakody SA, Gonzalez-Cordero A, Ali RR, Pearson RA.

Prog Retin Eye Res 2015;46:31-66.