David Gamm, MD, PhD
Co-Founder & Chief Scientific Officer
Dr. Gamm is a practicing pediatric ophthalmologist at the University of Wisconsin, and a leader in the field of retinal cell differentiation from human pluripotent stem cells. At the University of Wisconsin-Madison, Dave holds positions as RRF Emmett A. Humble Distinguished Director of the McPherson Eye Research Institute, Associate Professor of Ophthalmology and Visual Sciences, Sandra Lemke Trout Chair in Eye Research, and Principal Investigator in the Waisman Center Stem Cell Research Program and the UW Stem Cell and Regenerative Medicine Center. His laboratory at the Waisman Center utilizes stem cell technology to 1) investigate the cellular and molecular events that occur during human retinal differentiation and 2) generate cells for use in human retinal disease modeling and cell-based rescue or replacement strategies. Three-dimensional optic vesicle-based differentiation of human pluripotent stem cells into retinal cells, including photoreceptors, was first described in Dr. Gamm's laboratory.
Mr. Cliff is a serial entrepreneur with over 15 years of experience in biotech, principally focused on induced-pluripotent stem cell (iPSC)-based regenerative medicine. He is a founder of Opsis Therapeutics, RPRD Diagnostics, and Vascugen. During his tenure at FCDI, he established a pipeline of therapeutic development programs targeting age-related macular degeneration (AMD), heart failure, and Parkinson's disease. Previously he held various positions at leading platform technology companies including FUJIFILM Cellular Dynamics Inc. (FCDI), Meso Scale Discovery, Life Technologies (acquired by Thermo Fisher Scientific), and Ingenuity Systems (acquired by Qiagen).
Lucas Chase, PhD
Director, Research & Development
Dr. Chase is Director, Ocular Cell Therapy, at FUJIFILM Cellular Dynamics Inc. (FCDI), where he has led the development of induced pluripotent stem cell (iPSC)-based ocular therapeutics since 2014. Prior to that, he was Group Leader in Cell Biology R&D at CDI where he led efforts to develop a series of iPSC-derived neural cell models. Before joining CDI, Dr. Chase worked at Life Technologies (acquired by Thermo Fisher Scientific) where he focused on the development of cGMP stem cell culture medium, advanced cellular models and drug discovery assays. Dr. Chase obtained his Ph.D. in 2006 from the University of Minnesota - Twin Cities in the Molecular, Cellular, Developmental Biology and Genetics Program in the Lab of Dr. Catherine Verfaillie.
Joe Phillips, PhD
Director, Preclinical Studies
Dr. Phillips brings 17 years of retinal research experience to Opsis Therapeutics. His work has spanned the field of vision research, including pre-clinical testing for subretinal prosthetics (Optobionics, Atlanta VA hospital), visual psychophysics (University of Georgia), neuroprotective strategies (Emory University), and retinal stem cell and regenerative medicine (University of Wisconsin). He received a PhD in Vision Science from the University of Houston and is currently a lead scientist in Dr. David Gamm’s laboratory, where he spearheads stem cell derived photoreceptor production and transplantation studies in animal models of retinal disease. Dr. Phillips brings pertinent knowledge to this venture, including years of experience with animal models, retinal transplantation techniques and visual function testing.
Amanda Mack, PhD
Director, iPSC Technologies
Dr. Mack is Director, iPSC Reprogramming at FUJIFILM Cellular Dynamics Inc. (FCDI), where she has led the development of induced pluripotent stem cell (iPSC) technology since 2007. The iPSC platform is a core competency at CDI, and in 2013 it was was successfully implemented at CDI's facility in Novato, CA, where the world's largest bank of iPSC lines is being generated on behalf of a California Institute of Regenerative Medicine (CIRM)-funded project. Currently, she leads ongoing efforts to develop GMP-compliant protocols for therapeutic grade iPSCs , both autologous and haplotype-matched, which serve as the starting point for the development and manufacturing of a range of cell therapy products. Dr. Mack obtained her Ph.D. in Cancer Biology from the McArdle Laboratory for Cancer Research at the University of Wisconsin Madison under the mentorship of Dr. Bill Sugden in 2007.